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microbiology👍 3

Microbiological Assessment of Automated Teller Machine Keypads as Reservoirs of Potentially Pathogenic Bacteria in Nigerian Cities

Frequently touched public surfaces can serve as reservoirs for microbial contamination and facilitate transmission of potentially pathogenic organisms. Automated teller machine keypads are used daily by large numbers of individuals and may accumulate bacteria from diverse sources. The presence of antibiotic-resistant bacteria on these surfaces could contribute to community transmission of resistant pathogens. Understanding contamination patterns on public-use devices can inform hygiene awareness campaigns and public health interventions. This study seeks to evaluate bacterial contamination and resistance profiles associated with automated teller machine keypads.

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public-health👍 0

Determinants of Childhood Immunization Defaulting Among Caregivers Attending Primary Healthcare Facilities in Rural North-West Nigeria

Childhood immunization remains one of the most effective public health interventions for preventing vaccine-preventable diseases. Despite improvements in immunization coverage across Nigeria, several northern states continue to report suboptimal vaccination uptake and high rates of immunization defaulting. Factors such as vaccine hesitancy, poor healthcare access, low maternal education, cultural beliefs, insecurity, and health system constraints contribute to missed vaccination opportunities. Immunization defaulting increases the risk of disease outbreaks, childhood morbidity, and mortality. Understanding the specific factors influencing caregivers' adherence to vaccination schedules is essential for designing targeted interventions that improve vaccine completion rates. Evidence from rural communities remains limited despite their disproportionate burden of under-immunization. This study seeks to identify determinants of childhood immunization defaulting among caregivers attending primary healthcare facilities in rural North-West Nigeria and generate evidence to support context-specific immunization strategies.

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public-health👍 0

Knowledge, Risk Perception and Acceptance of Human Papillomavirus Vaccination Among Female Undergraduate Students in Nigerian Universities

Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women in Nigeria. Human papillomavirus vaccination offers a highly effective strategy for reducing the burden of cervical cancer. However, vaccine uptake remains low due to inadequate awareness, misconceptions, cultural concerns, cost barriers, and limited access. Female university students represent an important target population for preventive interventions because they are at an age where vaccination can still provide substantial benefits. Understanding knowledge levels, risk perception, and vaccine acceptance among young women is critical for developing effective awareness campaigns and vaccination programs. This study seeks to evaluate factors influencing acceptance of human papillomavirus vaccination among female undergraduate students in Nigerian universities.

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92 research topics available

microbiology

Prevalence and Molecular Detection of Helicobacter pylori Virulence Genes Among Dyspeptic Patients Attending Gastroenterology Clinics in Nigeria

Helicobacter pylori infection is highly prevalent in developing countries and is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. The pathogenicity of H. pylori is influenced by virulence genes such as cagA and vacA, which contribute to disease severity and clinical outcomes. Understanding the distribution of virulence-associated genes among local isolates is important for risk stratification and disease management. Despite the burden of H. pylori infection in Nigeria, limited molecular data exist regarding virulence gene profiles among infected patients.

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microbiology

Bacteriological Quality and Antibiotic Resistance Profiles of Fresh Vegetables Irrigated With Wastewater in Peri-Urban Farming Communities in Nigeria

The use of untreated wastewater for irrigation has become increasingly common in peri-urban agricultural communities due to water scarcity and economic pressures. While wastewater irrigation may improve crop production, it can introduce pathogenic and antibiotic-resistant bacteria into the food chain. Consumption of contaminated vegetables poses significant public health risks, particularly when produce is eaten raw. Monitoring bacterial contamination and resistance patterns is essential for ensuring food safety and preventing disease transmission. This study seeks to assess the bacteriological quality and antibiotic resistance profiles of bacteria isolated from vegetables irrigated with wastewater.

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microbiology

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Isolated From Nasal Carriers Among Healthcare Workers in Nigerian Tertiary Hospitals

Methicillin-resistant Staphylococcus aureus (MRSA) remains a major healthcare-associated pathogen responsible for significant morbidity, mortality, and increased healthcare costs. Healthcare workers can serve as asymptomatic reservoirs and facilitate transmission of MRSA within hospital settings. Colonization among healthcare personnel may contribute to outbreaks, particularly among vulnerable patients. Molecular characterization of MRSA strains provides valuable information regarding transmission dynamics and resistance mechanisms. Despite growing concerns regarding antimicrobial resistance, data on MRSA carriage among healthcare workers in many Nigerian hospitals remain limited. This study seeks to determine the prevalence and molecular characteristics of MRSA among healthcare workers in tertiary healthcare institutions.

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microbiology

Molecular Detection of Carbapenemase-Producing Acinetobacter baumannii Isolated From Intensive Care Units in Nigerian Tertiary Hospitals

Acinetobacter baumannii has emerged as a significant healthcare-associated pathogen due to its ability to survive in hospital environments and develop resistance to multiple antimicrobial agents. Carbapenem-resistant strains represent a major clinical challenge because treatment options are often limited. Intensive care units are particularly vulnerable to outbreaks caused by resistant Acinetobacter species. Molecular surveillance of carbapenemase-producing isolates is critical for infection control and antimicrobial stewardship programs. This study seeks to investigate the prevalence and molecular characteristics of carbapenemase-producing Acinetobacter baumannii in intensive care units.

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microbiology

Microbiological Quality and Biofilm-Forming Capacity of Bacterial Isolates Recovered From Hospital Water Distribution Systems in Nigeria

Hospital water systems can serve as reservoirs for opportunistic pathogens capable of causing healthcare-associated infections. Biofilm formation enhances bacterial survival, persistence, and resistance to disinfectants, making eradication difficult. Contaminated water systems may contribute to outbreaks among vulnerable patient populations. Understanding the microbiological quality of hospital water supplies and the biofilm-forming potential of associated bacteria is essential for infection prevention efforts. This study investigates bacterial contamination and biofilm formation among isolates recovered from hospital water distribution systems.

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microbiology

Occurrence of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Poultry Farms and Associated Public Health Risks in Nigeria

The use of antibiotics in poultry production has contributed to the emergence of antimicrobial-resistant bacteria with potential implications for human health. Extended-spectrum beta-lactamase-producing Enterobacteriaceae are of particular concern because of their resistance to commonly used antibiotics and ability to spread resistance genes across bacterial populations. Poultry farms may serve as reservoirs of resistant organisms that can be transmitted through food, the environment, or direct contact. This study seeks to investigate the occurrence and resistance characteristics of ESBL-producing Enterobacteriaceae in poultry production systems.

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microbiology

Prevalence and Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolated From Burn Wound Infections in Nigerian Teaching Hospitals

Burn wound infections remain a major cause of morbidity and mortality among hospitalized patients. Pseudomonas aeruginosa is a leading opportunistic pathogen associated with burn-related infections due to its intrinsic resistance mechanisms and ability to acquire additional resistance determinants. The emergence of multidrug-resistant strains significantly limits treatment options and increases healthcare costs. Understanding the prevalence, resistance patterns, and genetic diversity of clinical isolates is essential for infection control and antimicrobial stewardship. This study seeks to characterize multidrug-resistant Pseudomonas aeruginosa isolated from burn wound infections in Nigerian teaching hospitals.

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microbiology

Molecular Characterization and Antifungal Susceptibility Profiles of Candida Species Isolated From Vulvovaginal Candidiasis Cases in South-West Nigeria

Vulvovaginal candidiasis remains one of the most common fungal infections among women of reproductive age. While Candida albicans has traditionally been the predominant pathogen, emerging non-albicans Candida species have increasingly been implicated in clinical infections. These species often exhibit reduced susceptibility to commonly used antifungal agents, complicating treatment outcomes. In Nigeria, recurrent infections and widespread self-medication may contribute to the emergence of antifungal resistance. Molecular characterization of Candida species and evaluation of susceptibility patterns are essential for improving diagnosis and treatment strategies. This study seeks to investigate the species distribution and antifungal susceptibility profiles of Candida isolates from women diagnosed with vulvovaginal candidiasis.

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microbiology

Microbial Quality Assessment and Antibiotic Resistance Profiles of Bacteria Isolated From Borehole Water Sources in Peri-Urban Communities in Nigeria

Borehole water serves as a major source of drinking water for many Nigerian households. However, contamination of groundwater sources by pathogenic microorganisms poses significant public health risks. In addition to microbiological contamination, the presence of antibiotic-resistant bacteria in water systems has emerged as an environmental health concern. Monitoring microbial quality and resistance patterns is essential for ensuring safe water supplies and preventing disease outbreaks. This study seeks to assess microbial contamination and antibiotic resistance among bacterial isolates from borehole water sources.

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microbiology

Prevalence and Virulence Gene Profiles of Staphylococcus aureus Isolated From Healthcare Workers in Tertiary Hospitals in Nigeria

Healthcare workers can act as reservoirs and vectors for transmission of Staphylococcus aureus within healthcare settings. Colonization by virulent strains increases the risk of healthcare-associated infections among vulnerable patients. The presence of virulence genes contributes to pathogenicity and disease severity. Understanding colonization rates and virulence characteristics among healthcare workers is important for infection prevention and control. This study seeks to determine the prevalence and virulence gene profiles of Staphylococcus aureus among healthcare workers in tertiary hospitals.

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microbiology

Molecular Detection of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolated From Hospitalized Patients in Nigerian Teaching Hospitals

Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae has emerged as a major healthcare-associated pathogen associated with severe infections and treatment failures. These organisms possess enzymes capable of hydrolyzing broad-spectrum beta-lactam antibiotics, limiting therapeutic options. The burden of ESBL-producing organisms continues to increase in Nigerian healthcare facilities, creating challenges for infection control and antimicrobial stewardship. Molecular detection of ESBL genes is essential for surveillance and guiding appropriate treatment strategies. This study seeks to investigate the prevalence and molecular characteristics of ESBL-producing Klebsiella pneumoniae among hospitalized patients.

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microbiology

Occurrence and Antibiotic Resistance Patterns of Salmonella Species Isolated From Ready-to-Eat Street Foods Sold in Urban Markets in Nigeria

Ready-to-eat street foods provide affordable nutrition for millions of people in Nigeria but may serve as vehicles for foodborne pathogens when hygienic standards are inadequate. Salmonella species remain important causes of foodborne illnesses and can lead to significant morbidity. The emergence of antibiotic-resistant Salmonella strains further complicates treatment and outbreak control efforts. Monitoring the microbiological quality of street-vended foods is essential for protecting public health and improving food safety practices. This study seeks to determine the occurrence and antibiotic resistance profiles of Salmonella species isolated from ready-to-eat foods sold in urban markets.

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