Prevalence and Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolated From Burn Wound Infections in Nigerian Teaching Hospitals
Background
Burn wound infections remain a major cause of morbidity and mortality among hospitalized patients. Pseudomonas aeruginosa is a leading opportunistic pathogen associated with burn-related infections due to its intrinsic resistance mechanisms and ability to acquire additional resistance determinants. The emergence of multidrug-resistant strains significantly limits treatment options and increases healthcare costs. Understanding the prevalence, resistance patterns, and genetic diversity of clinical isolates is essential for infection control and antimicrobial stewardship. This study seeks to characterize multidrug-resistant Pseudomonas aeruginosa isolated from burn wound infections in Nigerian teaching hospitals.
Research Objectives
- Determine the prevalence of Pseudomonas aeruginosa in burn wound infections.
- Assess antimicrobial susceptibility patterns of the isolates.
- Identify multidrug-resistant strains.
- Characterize genetic diversity among isolates.
- Evaluate factors associated with multidrug resistance.
Research Questions
- What is the prevalence of Pseudomonas aeruginosa in burn wounds?
- What are the antimicrobial susceptibility profiles of the isolates?
- How common are multidrug-resistant strains?
- What genetic variations exist among the isolates?
- Which factors are associated with multidrug resistance?
Suggested Methodology
A laboratory-based study will be conducted using wound swab specimens collected from burn patients. Isolation and identification will be performed using standard microbiological techniques. Antimicrobial susceptibility testing and molecular typing methods will be employed. Statistical analyses will assess relationships between genetic profiles and resistance patterns.
Suggested Sample
Keywords
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