Antibiotic Resistance and Biofilm Production Among Coagulase-Negative Staphylococci Isolated From Indwelling Medical Devices in Nigerian Hospitals

Background

Coagulase-negative staphylococci have emerged as important opportunistic pathogens associated with medical device-related infections. Their ability to form biofilms enhances persistence on artificial surfaces and contributes to treatment failure. Biofilm-associated infections are difficult to eradicate because bacterial cells within biofilms often exhibit increased resistance to antimicrobial agents. Understanding resistance patterns and biofilm-forming capabilities among clinical isolates is essential for infection prevention and improved patient management. This study investigates antibiotic resistance and biofilm production among coagulase-negative staphylococci isolated from indwelling medical devices.

Research Objectives

• Determine the prevalence of coagulase-negative staphylococci on medical devices.
• Assess antimicrobial resistance patterns among isolates.
• Evaluate biofilm-forming capacity of the isolates.
• Examine associations between biofilm formation and resistance profiles.
• Identify factors associated with device-related colonization.

Research Questions

• What proportion of device-associated isolates are coagulase-negative staphylococci?
• What are the antimicrobial resistance profiles of the isolates?
• How prevalent is biofilm formation among isolates?
• Is biofilm formation associated with multidrug resistance?
• Which factors contribute to device colonization?

Suggested Methodology

Suggested Sample

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